Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only in Vivo

A. Teicher, Beverly; S. Herman, Terence; A. Holden, Sylvia; Wang, Yenyun; Raphael Pfeffer, M.; W. Crawford, James; Frei, Emil

doi:10.1126/science.2108497

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Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only in Vivo

Shared by NobleBlocks on Mar 23, 1990 • 12:00 AM UTC

Authors:

Beverly A. Teicher

Terence S. Herman

Sylvia A. Holden

Abstract

EMT-6 murine mammary tumors were made resistant to cis -diamminedichloroplatinum (II) (CDDP), carboplatin, cyclophosphamide (CTX), or thiotepa in vivo by treatment of tumor-bearing animals with the drug during a 6-month period. In spite of high levels of in vivo resistance, no significant resistance...

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