Aprotinin, cardiac surgery, and factor V Leiden.

D Sweeney, J; J Blair, A; P Dupuis, M; C King, T; L Moulton, A

doi:10.1046/j.1537-2995.1997.37111298088048.x

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Aprotinin, cardiac surgery, and factor V Leiden.

Shared by NobleBlocks on Sep 13, 2026 • 03:37 AM UTC

Authors:

J D Sweeney

A J Blair

M P Dupuis

Abstract

BACKGROUND: Aprotinin has been shown to reduce blood transfusion in cardiac surgery. Aprotinin inhibits activated protein C (APC). Patients with factor V (FV) Leiden have an inherited resistance to APC proteolysis. If the inhibition of APC by aprotinin contributes to its beneficial effect in cardiac...

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