Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

Isogai, Zenzo; N. Ono, Robert; Ushiro, Shin; R. Keene, Douglas; Chen, Yan; Mazzieri, Roberta; L. Charbonneau, Noé; P. Reinhardt, Dieter; B. Rifkin, Daniel; Y. Sakai, Lynn

doi:10.1074/jbc.m209256200

Public

Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

Published in Journal of Biological Chemistry • Jan 1, 2003

Authors:

Zenzo Isogai

Robert N. Ono

Shin Ushiro

Abstract

Latent transforming growth factor beta-binding protein 1 (LTBP-1) targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Fibrillins are extracellular matrix macromolecules whose pri...

Subject

Fibrillin

Extracellular matrix

Cell biology

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