Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders

Komatsu, Hidetoshi; Maruyama, Minoru; Shuuhei, Yao; Shinohara, Tokuyuki; Sakuma, Kensuke; Imaichi, Sachiko; Chikatsu, Tomoko; Kuniyeda, Kanako; Kok Siu, Foo; Sock Peng, Lam; Zhuo, Katherine; Sock Mun, Lay; Min Han, Tan; Matsumoto, Yoshio; Hashimoto, Tadatoshi; Miyajima, Nobuyuki; Itoh, Yasuaki; Ogi, Kazuhiro; Habata, Yugo; Mori, M.

doi:10.1371/journal.pone.0090134

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Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders

Published in PLoS ONE • Feb 28, 2014

Authors:

Hidetoshi Komatsu

Minoru Maruyama

Yao Shuuhei

Abstract

Many drugs of abuse and most neuropharmacological agents regulate G protein-coupled receptors (GPCRs) in the central nervous system (CNS)_ENREF_1. The striatum, in which dopamine D1 and D2 receptors are enriched, is strongly innervated by the ventral tegmental area (VTA), which is the origin of dopa...

Subject

Ventral tegmental area

Dopaminergic

Neuroscience

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