The complex between a tissue inhibitor of metalloproteinases (TIMP‐2) and 72‐kDa progelatinase is a metalloproteinase inhibitor

Kolkenbrock, H; Orgel, Dagmar; Hecker-Kia, Adelheid; NOACK, Wolfgang; Ulbrich, Norbert

doi:10.1111/j.1432-1033.1991.tb16080.x

Public

The complex between a tissue inhibitor of metalloproteinases (TIMP‐2) and 72‐kDa progelatinase is a metalloproteinase inhibitor

Published in European Journal of Biochemistry • Jun 1, 1991

Authors:

H Kolkenbrock

Dagmar Orgel

Adelheid Hecker-Kia

Abstract

Human rheumatoid synovial cells in culture secrete both 72-kDa progelatinase and a complex consisting of 72-kDa progelatinase and a 24-kDa inhibitor of metalloproteinases, TIMP-2. In addition, the culture medium contains TIMP-1, the classical inhibitor of metalloproteinases, with a molecular mass of...

Subject

Matrix metalloproteinase

Gelatinase

Tissue inhibitor of metalloproteinase

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