Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

Reuse, S.; Calao, Miriam; Kabeya, Kabamba; Guiguen, Allan; Gatot, Jean‐Stéphane; Quivy, Vincent; Vanhulle, Caroline; Lamine, Aurélia; Vaira, Dolorès; Demonté, Dominique; Martinelli, Valérie; Veithen, Emmanuelle; Cherrier, Thomas; Avettand-Fènoël, Véronique; Poutrel, Solène; Piette, Jacques; de Launoit, Yvan; Moutschen, Michel; Burny, Arsène; Rouzioux, Christine; De Wit, Stéphane; Herbein, Georges; Rohr, Olivier; Collette, Yves; Lambotte, Olivier; Clumeck, Nathan; Van Lint, Carine

doi:10.1371/journal.pone.0006093

Public

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

Published in PLoS ONE • Jun 29, 2009

Authors:

S. Reuse

Miriam Calao

Kabamba Kabeya

Abstract

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these cells together with an efficient HAART ha...

Subject

HIV Long Terminal Repeat

Histone deacetylase

Biology

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