Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

Liao, Jianqun; Qian, Feng; Tchabo, Nana; Mhawech‐Fauceglia, Paulette; Beck, Amy; Zikun, Qian; Wang, Xinhui; J. Huss, Wendy; Lele, Shashikant; D. Morrison, Carl; Odunsi, Kunle

doi:10.1371/journal.pone.0084941

Public

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

Published in PLoS ONE • Jan 7, 2014

Authors:

Jianqun Liao

Feng Qian

Nana Tchabo

Abstract

Cells with sphere forming capacity, spheroid cells, are present in the malignant ascites of patients with epithelial ovarian cancer (EOC) and represent a significant impediment to efficacious treatment due to their putative role in progression, metastasis and chemotherapy resistance. The exact mecha...

Subject

Cancer stem cell

Cancer research

Ovarian cancer

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