Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion

G. Frangogiannis, Nikolaos; L. Lindsey, Merry; H. Michael, Lloyd; A. Youker, Keith; B. Bressler, Robert; H. Mendoza, Leonardo; N. Spengler, Robert; Wayne Smith, C.; L. Entman, Mark

doi:10.1161/01.cir.98.7.699

Public

Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion

Published in Circulation • Aug 18, 1998

Authors:

Nikolaos G. Frangogiannis

Merry L. Lindsey

Lloyd H. Michael

Abstract

BACKGROUND: Neutrophil-induced cardiomyocyte injury requires the expression of myocyte intercellular adhesion molecule (ICAM)-1 and ICAM-1-CD11b/CD18 adhesion. We have previously demonstrated interleukin (IL)-6 activity in postischemic cardiac lymph; IL-6 is the primary stimulus for myocyte ICAM- 1 ...

Subject

Medicine

Cytokine

Ischemia

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