γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

Serneels, Lutgarde; Van Biervliet, Jérôme; Craessaerts, Katleen; Dejaegere, Tim; Horré, Katrien; Van Houtvin, Tine; Esselmann, Hermann; Paul, Sabine; Schäfer, Martin; Berezovska, Oksana; T. Hyman, Bradley; Sprangers, Ben; Sciot, Raf; Moons, Lieve; Jucker, Mathias; Yang, Zhixiang; C. May, Patrick; Karran, Eric; Wiltfang, Jens; D’Hooge, Rudi; De Strooper, Bart

doi:10.1126/science.1171176

Public

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

Published in Science • Mar 19, 2009

Authors:

Lutgarde Serneels

Jérôme Van Biervliet

Katleen Craessaerts

Abstract

The gamma-secretase complex plays a role in Alzheimer's disease and cancer progression. The development of clinically useful inhibitors, however, is complicated by the role of the gamma-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins. Different gamma-se...

Subject

Presenilin

Gamma secretase

Proteolysis

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