Effect of a novel 5‐HT<sub>3</sub> receptor agonist MKC‐733 on upper gastrointestinal motility in humans

Coleman, Nicholas; Marciani, Luca; Blackshaw, Elaine; Wright, Jeff; G. Parker, Margaret; Yano, T.; Yamazaki, Satoshi; Chan, Philippe; Wilde, K.; Gowland, Penny; C. Perkins, Alan; E. Spiller, Robert

doi:10.1046/j.1365-2036.2003.01797.x

Public

Effect of a novel 5‐HT3 receptor agonist MKC‐733 on upper gastrointestinal motility in humans

Published in Alimentary Pharmacology & Therapeutics • Nov 1, 2003

Authors:

Nicholas Coleman

Luca Marciani

Elaine Blackshaw

Abstract

BACKGROUND: Although 5-HT3 antagonists have been used to treat chemotherapy-induced emesis and diarrhoea-predominant irritable bowel syndrome, the effects of 5-HT3 agonists in humans are unknown. AIM: To determine the effect of MKC-733, a selective 5-HT3 receptor agonist, on upper gastrointestinal m...

Subject

Gastric emptying

Antrum

Medicine

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