Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1)

Bonderman, Diana; Pretsch, Ingrid; Steringer‐Mascherbauer, Regina; Jansa, Pavel; Rosenkranz, Stephan; Tufaro, Caroline; Bojic, Andja; S.P. Lam, Carolyn; Frey, Reiner; Ochan Kilama, Michael; Unger, Sigrun; Roessig, Lothar; Lang, Iréne

doi:10.1378/chest.14-0106

Public

Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1)

Published in CHEST Journal • Jul 3, 2014

Authors:

Diana Bonderman

Ingrid Pretsch

Regina Steringer‐Mascherbauer

Abstract

BACKGROUND: Deficient nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and pulmonary hypertension ...

Subject

Medicine

Riociguat

Internal medicine

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