Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

Pan, Xiaodong; Zhu, Yuangui; Lin, Nan; Zhang, Jing; Ye, Qin-yong; Huang, Huapin; Chen, Xiaochun

doi:10.1186/1750-1326-6-45

Public

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

Published in Molecular Neurodegeneration • Jun 30, 2011

Authors:

Xiaodong Pan

Yuangui Zhu

Nan Lin

Abstract

BACKGROUND: Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly exist in an "activated" state. Oligomeric Aβ (...

Subject

Phagocytosis

Microglia

Chemistry

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