MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

Verstak, Brett; Nagpal, Kamalpreet; Bottomley, Stephen; T. Golenbock, Douglas; J. Hertzog, Paul; Mansell, Ashley

doi:10.1074/jbc.m109.023044

Public

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

Published in Journal of Biological Chemistry • Jul 11, 2009

Authors:

Brett Verstak

Kamalpreet Nagpal

Stephen Bottomley

Abstract

Toll/interleukin-1 (TIR)receptor-containing adapters are critical in orchestrating the different signal transduction pathways following Toll-like receptor (TLR) activation. MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling...

Subject

Proinflammatory cytokine

Transactivation

TLR4

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