The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia

Q. Cunha, Fernando; Poole, Stephen; B. Lorenzetti, B.; H. Ferreira, S.

doi:10.1111/j.1476-5381.1992.tb14503.x

Public

The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia

Published in British Journal of Pharmacology • Nov 1, 1992

Authors:

Fernando Q. Cunha

Stephen Poole

B. B. Lorenzetti

Abstract

1. The hyperalgesic activities in rats of interleukin-1 beta (IL-1 beta), IL-6, IL-8, tumour necrosis factor alpha (TNF alpha) and carrageenin were investigated. 2. IL-6 activated the previously delineated IL-1/prostaglandin hyperalgesic pathway but not the IL-8/sympathetic mediated hyperalgesic pat...

Subject

Hyperalgesia

Tumor necrosis factor alpha

Endogeny

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