Chemical and Enzymatic Synthesis and Antiviral Properties of 2′-Deoxy-2′-fluoroguanosine

В. Зайцева, Г.; И. Зинченко, А.; N. Barai, V.; I. Pavlova, N.; I. Boreko, Evgeny; A. Mikhailopulo, Igor

doi:10.1080/15257779908041541

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Chemical and Enzymatic Synthesis and Antiviral Properties of 2′-Deoxy-2′-fluoroguanosine

Published in Nucleosides and Nucleotides • Apr 1, 1999

Authors:

Г. В. Зайцева

А. И. Зинченко

V. N. Barai

Abstract

Chemical and enzymatic methods were employed for the synthesis of the title compound, 2'F-Guo 7. High antiviral activity of 2'F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).

Subject

Enzyme

Herpes simplex virus

Virus

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