Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

Ghosh, Simantini; D. Wu, Michael; S. Shaftel, Solomon; Kyrkanides, Stephanos; M. LaFerla, Frank; A. Olschowka, John; Kerry O'Banion, M.

doi:10.1523/jneurosci.4361-12.2013

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Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

Shared by NobleBlocks on Mar 13, 2013 • 12:00 AM UTC

Authors:

Simantini Ghosh

Michael D. Wu

Solomon S. Shaftel

Abstract

Neuroinflammation is an important component of Alzheimer's disease (AD) pathogenesis and has been implicated in neurodegeneration. Interleukin-1 (IL-1), a potent inflammatory cytokine in the CNS, is chronically upregulated in human AD and believed to serve as part of a vicious inflammatory cycle tha...

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