Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine

Brusq, Jean‐Marie; Ancellin, Nicolas; Grondin, Pascal; Guillard, Raphaëlle; Martin, Sandrine; Saintillan, Yannick; Issandou, Marc

doi:10.1194/jlr.m600020-jlr200

Public

Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine

Published in Journal of Lipid Research • Mar 1, 2006

Authors:

Jean‐Marie Brusq

Nicolas Ancellin

Pascal Grondin

Abstract

The alkaloid drug berberine (BBR) was recently described to decrease plasma cholesterol and triglycerides (TGs) in hypercholesterolemic patients by increasing expression of the hepatic low density lipoprotein receptor (LDLR). Using HepG2 human hepatoma cells, we found that BBR inhibits cholesterol a...

Subject

AMPK

Berberine

Activator (genetics)

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