Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

J. Devine, Michael; Ryten, Mina; Vodička, Petr; J. Thomson, Alison; Burdon, Tom; Houlden, Henry; Cavaleri, Fatima; Nagano, Masumi; J. Drummond, Nicola; Taanman, Jan‐Willem; H.V. Schapira, Anthony; Gwinn, Katrina; Hardy, John; A. Lewis, Patrick; Kunath, Tilo

doi:10.1038/ncomms1453

Public

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

Published in Nature Communications • Aug 23, 2011

Authors:

Michael J. Devine

Mina Ryten

Petr Vodička

Abstract

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells from patients and differentiate them into neurons affected by disease. Triplication of SNCA, encoding α-synuclein, causes a fully penetrant, ag...

Subject

Induced pluripotent stem cell

Neurodegeneration

Parkinson's disease

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