Cytochrome P-450 Polymorphisms and Response to Clopidogrel

L. Mega, Jessica; Close, Sandra; D. Wiviott, Stephen; Shen, Lei; D. Hockett, Richard; T. Brandt, John; R. Walker, Joseph; M. Antman, Elliott; L. Macias, William; Braunwald, Eugene; S. Sabatine, Marc

doi:10.1056/nejmoa0809171

Public

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

Published in New England Journal of Medicine • Dec 22, 2008

Authors:

Jessica L. Mega

Sandra Close

Stephen D. Wiviott

Abstract

BACKGROUND: Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function. METHODS: We tested the association between functional genetic vari...

Subject

Medicine

Clopidogrel

Cytochrome

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