Rqc2p and 60 S ribosomal subunits mediate mRNA-independent elongation of nascent chains

Shen, Peter; Park, Joseph; Qin, Yidan; Li, Xueming; Parsawar, Krishna; H. Larson, Matthew; E. Cox, James; Cheng, Yifan; M. Lambowitz, Alan; S. Weissman, Jonathan; Brandman, Onn; Frost, Adam

doi:10.1126/science.1259724

Public

Rqc2p and 60 S ribosomal subunits mediate mRNA-independent elongation of nascent chains

Published in Science • Jan 1, 2015

Authors:

Peter Shen

Joseph Park

Yidan Qin

Abstract

In Eukarya, stalled translation induces 40S dissociation and recruitment of the ribosome quality control complex (RQC) to the 60S subunit, which mediates nascent chain degradation. Here we report cryo-electron microscopy structures revealing that the RQC components Rqc2p (YPL009C/Tae2) and Ltn1p (YM...

Subject

Elongation

Ribosomal RNA

Messenger RNA

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!