Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

DiFiglia, Marian; Sapp, Ellen; O. Chase, Kathryn; W. Davies, Stephen; P. Bates, Gillian; P. Vonsattel, J.; Aronin, Neil

doi:10.1126/science.277.5334.1990

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Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Shared by NobleBlocks on Sep 26, 1997 • 12:00 AM UTC

Authors:

Marian DiFiglia

Ellen Sapp

Kathryn O. Chase

Abstract

The cause of neurodegeneration in Huntington's disease (HD) is unknown. Patients with HD have an expanded NH 2 -terminal polyglutamine region in huntingtin. An NH 2 -terminal fragment of mutant huntingtin was localized to neuronal intranuclear inclusions (NIIs) and dystrophic neurites (DNs) in the H...

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