<i>miR-15</i> and <i>miR-16</i> induce apoptosis by targeting BCL2

Cimmino, Amelia; A. Calin, George; Fabbri, Muller; V. Iorio, Marilena; Ferracin, Manuela; Shimizu, Masayoshi; E. Wojcik, Sylwia; I. Aqeilan, Rami; Zupo, Simona; Dono, Mariella; Z. Rassenti, Laura; Alder, Hansjüerg; Volinia, Stefano; Liu, Chang‐Gong; J. Kipps, Thomas; Negrini, Massimo; M. Croce, Carlo

doi:10.1073/pnas.0506654102

Public

miR-15 and miR-16 induce apoptosis by targeting BCL2

Published in Proceedings of the National Academy of Sciences • Sep 15, 2005

Authors:

Amelia Cimmino

George A. Calin

Muller Fabbri

Abstract

Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate...

Subject

microRNA

Chronic lymphocytic leukemia

Cancer research

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