A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse

Xiao, Hongde; Xin, Kai; Dou, Haifang; Yin, Gui; Quan, Yiwu; Wang, Ruiyong

doi:10.1039/c4cc07411d

Public

A fast-responsive mitochondria-targeted fluorescent probe detecting endogenous hypochlorite in living RAW 264.7 cells and nude mouse

Published in Chemical Communications • Dec 2, 2014

Authors:

Hongde Xiao

Kai Xin

Haifang Dou

Abstract

A very fast-responsive fluorescent probe PZ-Py for imaging mitochondrial HClO/ClO(-), with a relatively long emission wavelength, was prepared. The limit of detection was evaluated to be 17.9 nM. Moreover, the probe PZ-Py was successfully applied in the imaging of endogenous HClO/ClO(-) in the mitoc...

Subject

Endogeny

Hypochlorite

Fluorescence

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