NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

K. Pfeffer, Carsten; Stein, Valentin; J. Keating, Damien; Maier, H.; Rinke, Ilka; Rudhard, York; Hentschke, Moritz; M. Rune, Gabriele; J. Jentsch, Thomas; A. Hübner, Christian

doi:10.1523/jneurosci.1377-08.2009

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NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

Published in Journal of Neuroscience • Mar 18, 2009

Authors:

Carsten K. Pfeffer

Valentin Stein

Damien J. Keating

Abstract

A high intracellular chloride concentration in immature neurons leads to a depolarizing action of GABA that is thought to shape the developing neuronal network. We show that GABA-triggered depolarization and Ca2+ transients were attenuated in mice deficient for the Na-K-2Cl cotransporter NKCC1. Corr...

Subject

GABAergic

Glutamatergic

Depolarization

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