A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

A. Seibold, Max; L. Wise, Anastasia; C. Speer, Marcy; P. Steele, Mark; M. Brown, Kevin; E. Loyd, James; E. Fingerlin, Tasha; Zhang, Weiming; Guðmundsson, Gunnar; D. Groshong, Steve; M. Evans, Christopher; Garantziotis, Stavros; B. Adler, Kenneth; F. Dickey, Burton; M. du Bois, Roland; V. Yang, Ivana; Herron, Aretha; Kervitsky, Dolly; Talbert, Janet; Markin, Cheryl; Park, Joungjoa; L. Crews, Anne; H. Slifer, Susan; S. Auerbach, Scott; G. Roy, Michelle; Lin, Jia; E. Hennessy, Corinne; I. Schwarz, Marvin; A. Schwartz, David

doi:10.1056/nejmoa1013660

Public

A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

Published in New England Journal of Medicine • Apr 20, 2011

Authors:

Max A. Seibold

Anastasia L. Wise

Marcy C. Speer

Abstract

BACKGROUND: The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk. METHODS: Using a genomewide linkage scan, we detected linkage between idiopathic interstitial pneumonia and a 3.4-Mb region of chromosome 11p15 in 82 families. We the...

Subject

Medicine

Pulmonary fibrosis

Polymorphism (computer science)

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