A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B.

TT, Chang; RG, Gish; Man R, de; A, Gadano; J, Sollano; YC, Chao; AS, Lok; KH, Han; Z, Goodman; J, Zhu; A, Cross; D, DeHertogh; R, Wilber; R, Colonno; D, Apelian

doi:10.1056/nejmoa051285

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A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B.

Shared by NobleBlocks on Mar 1, 2006 • 12:00 AM UTC

Authors:

Chang TT

Gish RG

de Man R

Abstract

Background Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV).Methods In this phase 3, double-blind trial, we randomly assigned 715 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B who had not previously received a...

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