Human-specific gene
                    <i>ARHGAP11B</i>
                    promotes basal progenitor amplification and neocortex expansion

Florio, Marta; Albert, Mareike; Taverna, Elena; Namba, Takashi; Brandl, Holger; Lewitus, Eric; Haffner, Christiane; Sykes, Alex; Kuan Wong, Fong; Peters, Jula; Guhr, Elaine; Klemroth, Sylvia; Prüfer, Kay; Kelso, Janet; Naumann, Ronald; Nüsslein, Ina; Dahl, Andreas; Lachmann, Robert; Pääbo, Svante; B. Huttner, Wieland

doi:10.1126/science.aaa1975

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Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

Shared by NobleBlocks on Mar 27, 2015 • 12:00 AM UTC

Authors:

Marta Florio

Mareike Albert

Elena Taverna

Abstract

Build the builders before the brain Humans are much smarter than mice—key to this is the relative thickness of the human brain's neocortex. Florio et al. combed through genes expressed in the progenitor cells that build the neocortex and zeroed in on one gene found in humans but not in mice. The gen...

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