Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by<i>tert</i>-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

D. Kraft, Andrew; A. Johnson, Delinda; A. Johnson, Jeffrey

doi:10.1523/jneurosci.3817-03.2004

Public

Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation bytert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

Published in Journal of Neuroscience • Feb 4, 2004

Authors:

Andrew D. Kraft

Delinda A. Johnson

Jeffrey A. Johnson

Abstract

Binding of the transcription factor nuclear factor E2-related factor 2 (Nrf2) to the antioxidant response element (ARE) in neural cells results in the induction of a battery of genes that can coordinate a protective response against a variety of oxidative stressors. In this study, tert-butylhydroqui...

Subject

Neuroprotection

Population

Biology

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