Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia.

W, Yang; Y, Song; YL, Lu; JZ, Sun; HW, Wang

doi:10.1111/imm.12101

Public

Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia.

Shared by NobleBlocks on Aug 1, 2013 • 12:00 AM UTC

Authors:

Yang W

Song Y

Lu YL

Abstract

Impaired local cellular immunity contributes to the pathogenesis of persistent high-risk human papillomavirus (HR-HPV) infection and related cervical intraepithelial neoplasia (CIN), but the underlying molecular mechanisms remain unclear. Recently, the programmed death 1/programmed death 1 ligand (P...

Subject

Cytokines

Human papillomavirus

Programmed death-1

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