A randomized comparison of liposomal versus conventional amphotericin B for the treatment of pyrexia of unknown origin in neutropenic patients

G. Prentice, H.; Hann, Ian; Herbrecht, Raoul; Aoun, Mabel; Kvaløy, Stein; Catovsky, Daniel; Pinkerton, CR; Schey, Steve; Jacobs, F.; Oakhill, A; Stevens, Richard; Darbyshire, Philip; Gibson, B

doi:10.1046/j.1365-2141.1997.2473063.x

Public

A randomized comparison of liposomal versus conventional amphotericin B for the treatment of pyrexia of unknown origin in neutropenic patients

Published in British Journal of Haematology • Sep 1, 1997

Authors:

H. G. Prentice

Ian Hann

Raoul Herbrecht

Abstract

One hundred and thirty-four adults and 204 children were randomized in two prospective, parallel comparative multicentre trials to receive either conventional amphotericin B 1 mg/kg/d (c-AMB), liposomal amphotericin B 1 mg/kg/d(L-AMB1) or liposomal amphotericin B 3 mg/ kg/d (L-AMB3). Patients were e...

Subject

Nephrotoxicity

Neutropenia

Amphotericin B

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