Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy

M. Thomas, Pamela; J. Cote, Gilbert; Wohllk, Nelson; Haddad, Bassem; M. Mathew, P.; Rabl, Wolfgang; Aguilar-Bryan, Lydia; F. Gagel, Robert; Bryan, Joseph

doi:10.1126/science.7716548

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Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy

Shared by NobleBlocks on Apr 21, 1995 • 12:00 AM UTC

Authors:

Pamela M. Thomas

Gilbert J. Cote

Nelson Wohllk

Abstract

Familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion, is linked to chromosome 11p14-15.1. The newly cloned high-affinity sulfonylurea receptor ( SUR ) gene, a regulator of insulin secretion, was mapped to ...

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