Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma

Desai, Dhananjay; Newby, Chris; A. Symon, Fiona; Haldar, Pranabashis; Shah, Sachil; Gupta, Sumit; Bafadhel, Mona; Singapuri, Amisha; Siddiqui, Salman; Woods, Joanne; Herath, Athula; K. Anderson, Ian; Bradding, Peter; Green, Ruth; Shrikant Kulkarni, Nita; Pavord, Ian; P. Marshall, Richard; R. Sousa, Ana; May, Richard; J. Wardlaw, Andrew; E. Brightling, Christopher

doi:10.1164/rccm.201208-1470oc

Public

Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma

Published in American Journal of Respiratory and Critical Care Medicine • May 8, 2013

Authors:

Dhananjay Desai

Chris Newby

Fiona A. Symon

Abstract

RATIONALE: The relationship between airway inflammation and obesity in severe asthma is poorly understood. OBJECTIVES: We sought to determine the relationship between sputum mediator profiles and the distribution of eosinophilic inflammation and obesity in people with severe asthma. METHODS: Clinica...

Subject

Medicine

Body mass index

Sputum

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