Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

Legat, Amandine; E. Speiser, Daniel; Pircher, Hanspeter; Zehn, Dietmar; A. Fuertes Marraco, Silvia

doi:10.3389/fimmu.2013.00455

Public

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

Published in Frontiers in Immunology • Jan 1, 2013

Authors:

Amandine Legat

Daniel E. Speiser

Hanspeter Pircher

Abstract

Under conditions of chronic antigen stimulation, such as persistent viral infection and cancer, CD8 T cells may diminish effector function, which has been termed "exhaustion." Expression of inhibitory Receptors (iRs) is often regarded as a hallmark of "exhaustion." Here we studied the expression of ...

Subject

CD28

Cytotoxic T cell

CD8

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