Dynamic changes in the human methylome during differentiation

C. Laurent, Louise; Wong, Eleanor; Li, Guoliang; Huynh, Tien; Tsirigos, Aristotelis; Thing Ong, Chin; Meng Low, Hwee; Wing Kin Sung, Ken; Rigoutsos, Isidore; F. Loring, Jeanne; Wei, Chia‐Lin

doi:10.1101/gr.101907.109

Public

Dynamic changes in the human methylome during differentiation

Published in Genome Research • Feb 4, 2010

Authors:

Louise C. Laurent

Eleanor Wong

Guoliang Li

Abstract

DNA methylation is a critical epigenetic regulator in mammalian development. Here, we present a whole-genome comparative view of DNA methylation using bisulfite sequencing of three cultured cell types representing progressive stages of differentiation: human embryonic stem cells (hESCs), a fibroblas...

Subject

Biology

DNA methylation

Methylation

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