Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

M. Graham, Susan; G. Jørgensen, Heather; Allan, Elaine; Pearson, Charlie; J. Alcorn, Michael; Richmond, Linda; L. Holyoake, Tessa

doi:10.1182/blood.v99.1.319

Public

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

Published in Blood • Jan 1, 2002

Authors:

Susan M. Graham

Heather G. Jørgensen

Elaine Allan

Abstract

In clinical trials, the tyrosine kinase inhibitor STI571 has proven highly effective in reducing leukemic cell burden in chronic myeloid leukemia (CML). The overall sensitivity of CML CD34(+) progenitor cells to STI571 and the degree to which cell death was dependent on cell cycle status were determ...

Subject

Biology

Stem cell

Myeloid leukemia

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