Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

Pyo, Robert; K. Lee, Jason; Michael Shipley, J.; A. Curci, John; Mao, Dongli; J. Ziporin, Scott; L. Ennis, Terri; D. Shapiro, Steven; M. Senior, Robert; W. Thompson, Robert

doi:10.1172/jci8931

Public

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

Published in Journal of Clinical Investigation • Jun 1, 2000

Authors:

Robert Pyo

Jason K. Lee

J. Michael Shipley

Abstract

Abdominal aortic aneurysms represent a life-threatening condition characterized by chronic inflammation, destructive remodeling of the extracellular matrix, and increased local expression of matrix metalloproteinases (MMPs). Both 92-kD gelatinase (MMP-9) and macrophage elastase (MMP-12) have been im...

Subject

Matrix metalloproteinase

Aortic aneurysm

Abdominal aortic aneurysm

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