Integrin αVβ3 Contains a Cell Surface Receptor Site for Thyroid Hormone that Is Linked to Activation of Mitogen-Activated Protein Kinase and Induction of Angiogenesis

J. Bergh, Joel; Lin, Hung-Yun; Lansing, Lawrence; N. Mohamed, Seema; B. Davis, Faith; Mousa, Shaker; J. Davis, Paul

doi:10.1210/en.2005-0102

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Integrin αVβ3 Contains a Cell Surface Receptor Site for Thyroid Hormone that Is Linked to Activation of Mitogen-Activated Protein Kinase and Induction of Angiogenesis

Shared by NobleBlocks on Jul 1, 2005 • 12:00 AM UTC

Authors:

Joel J. Bergh

Hung-Yun Lin

Lawrence Lansing

Abstract

Abstract Integrin αVβ3 is a heterodimeric plasma membrane protein whose several extracellular matrix protein ligands contain an RGD recognition sequence. This study identifies integrin αVβ3 as a cell surface receptor for thyroid hormone [l-T4 (T4)] and as the initiation site for T4-induced activatio...

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