Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: Possible role in subchondral bone sclerosis

Hilal, George; Martel-Pelletier, Johanne; Pelletier, Jean‐Pierre; Ranger, Pierre; Lajeunesse, Daniel

doi:10.1002/1529-0131(199805)41:5<891::aid-art17>3.0.co;2-x

Public

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: Possible role in subchondral bone sclerosis

Published in Arthritis & Rheumatism • May 1, 1998

Authors:

George Hilal

Johanne Martel-Pelletier

Jean‐Pierre Pelletier

Abstract

OBJECTIVE: Osteoarthritis (OA) is accompanied by subchondral bone sclerosis. The present study was undertaken to determine whether osteoblast-like cells in patients with OA show an abnormal phenotype that could contribute to this sclerosis. METHODS: Explants and primary in vitro osteoblast-like cell...

Subject

Osteoblast

Osteocalcin

Endocrinology

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