Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

Guo, Liang; Chen, C; Shi, Ming; Wang, Fei; Chen, X; Diao, Dongmei; Hu, Min; Yu, Min; Lu, Qian; Guo, Ning

doi:10.1038/onc.2012.573

Public

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

Published in Oncogene • Jan 14, 2013

Authors:

Liang Guo

C Chen

Ming Shi

Abstract

Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice....

Subject

Biology

Oncostatin M

Epithelial–mesenchymal transition

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