Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

Salloum, Shadi; Wang, Hongliang; Ferguson, Charles; G. Parton, Robert; W. Tai, Andrew

doi:10.1371/journal.ppat.1003513

Public

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

Published in PLoS Pathogens • Aug 1, 2013

Authors:

Shadi Salloum

Hongliang Wang

Charles Ferguson

Abstract

Hepatitis C virus (HCV) is a single-stranded RNA virus that replicates on endoplasmic reticulum-derived membranes. HCV particle assembly is dependent on the association of core protein with cellular lipid droplets (LDs). However, it remains uncertain whether HCV assembly occurs at the LD membrane it...

Subject

NS5A

Endoplasmic reticulum

Lipid droplet

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