Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

Marullo, Rossella; Werner, Erica; Degtyareva, Natalya; S. Moore, Bryn; Altavilla, Giuseppe; S. Ramalingam, Suresh; W. Doetsch, Paul

doi:10.1371/journal.pone.0081162

Public

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

Published in PLoS ONE • Nov 19, 2013

Authors:

Rossella Marullo

Erica Werner

Natalya Degtyareva

Abstract

Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is thought to be mediated primarily by the generation of nuclear DNA adducts, which, if not repaired, cause cell death as a consequence of DNA repl...

Subject

Cisplatin

DNA damage

Mitochondrial DNA

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