Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New Vectors

Verzeletti, Simona; Bonini, Chiara; Marktel, Sarah; Nobili, Nadia; Ciceri, Fabio; Traversari, Catia; Bordignon, Claudio

doi:10.1089/hum.1998.9.15-2243

Public

Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New Vectors

Published in Human Gene Therapy • Oct 10, 1998

Authors:

Simona Verzeletti

Chiara Bonini

Sarah Marktel

Abstract

We previously demonstrated that severe graft-versus-host disease (GvHD), associated with the therapeutic infusion of donor lymphocytes after allogeneic marrow transplantation (BMT), can be efficiently controlled by the SFCMM-2-mediated expression of the herpes simplex virus thymidine kinase (HSV-tk)...

Subject

Thymidine kinase

Gene transfer

Herpes simplex virus

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