Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors.

S, Verzeletti; C, Bonini; S, Marktel; N, Nobili; F, Ciceri; C, Traversari; C, Bordignon

doi:10.1089/hum.1998.9.15-2243

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Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors.

Shared by NobleBlocks on Oct 1, 1998 • 12:00 AM UTC

Authors:

Verzeletti S

Bonini C

Marktel S

Abstract

We previously demonstrated that severe graft-versus-host disease (GvHD), associated with the therapeutic infusion of donor lymphocytes after allogeneic marrow transplantation (BMT), can be efficiently controlled by the SFCMM-2-mediated expression of the herpes simplex virus thymidine kinase (HSV-tk)...

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