Transgenerational Glucose Intolerance With <i>Igf2</i>/<i>H19</i> Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia

Ding, Guo-Lian; Wang, Fang-Fang; Shu, Jing; Tian, Shen; Jiang, Ying; Zhang, Dan; Wang, Ning; Luo, Qiong; Zhang, Yu; Jin, Fan; C.K. Leung, Peter; Sheng, Jian-Zhong; Huang, He-Feng

doi:10.2337/db11-1314

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Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia

Shared by NobleBlocks on Apr 13, 2012 • 12:00 AM UTC

Authors:

Guo-Lian Ding

Fang-Fang Wang

Jing Shu

Abstract

Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of diabetes in offspring. However, the mechanisms involved and the possibilities of transgenerational transmission are still unclear. We intercrossed male and female adult control and first-generation offspring of GDM...

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