Critical Role of Hypoxia Sensor - HIF-1α in VEGF Gene Activation. Implications for Angiogenesis and Tissue Injury Healing

Ahluwalia, Amrita; Tarnawski, A

doi:10.2174/092986712803413944

Public

Critical Role of Hypoxia Sensor - HIF-1α in VEGF Gene Activation. Implications for Angiogenesis and Tissue Injury Healing

Published in Current Medicinal Chemistry • Jan 1, 2012

Authors:

Amrita Ahluwalia

A Tarnawski

Abstract

Vascular injury of esophageal and gastrointestinal mucosa caused by injurious and ulcerogenic factors leads to the cessation of blood flow, ischemia, and hypoxia and tissue necrosis in form of erosions or ulcers. The re-establishment of blood vessels through the process of angiogenesis--formation of...

Subject

Angiogenesis

Hypoxia (environmental)

Cancer research

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