Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

Paul Aiello, Lloyd; Bursell, Sven–Erik; C. Clermont, Allen; J. Duh, Elia; Ishii, Hidehiro; Takagi, Chikako; Mori, Fumi; A. Ciulla, Thomas; Ways, Kirk; R. Jirousek, Michael; E. H. Smith, Lois; L. King, George

doi:10.2337/diab.46.9.1473

Public

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

Published in Diabetes • Sep 1, 1997

Authors:

Lloyd Paul Aiello

Sven–Erik Bursell

Allen C. Clermont

Abstract

Increased vascular permeability and excessive neovascularization are the hallmarks of endothelial dysfunction, which can lead to diabetic macular edema and proliferative diabetic retinopathy in the eye. Vascular endothelial growth factor (VEGF) is an important mediator of ocular neovascularization a...

Subject

Vascular permeability

Protein kinase C

Vascular endothelial growth factor

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