Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

Rocheville, Magalie; C. Lange, Daniela; Kumar, Ujendra; C. Patel, Shutish; C. Patel, Ramesh; Patel, Yogesh

doi:10.1126/science.288.5463.154

Public

Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

Published in Science • Apr 7, 2000

Authors:

Magalie Rocheville

Daniela C. Lange

Ujendra Kumar

Abstract

Somatostatin and dopamine are two major neurotransmitter systems that share a number of structural and functional characteristics. Somatostatin receptors and dopamine receptors are colocalized in neuronal subgroups, and somatostatin is involved in modulating dopamine-mediated control of motor activi...

Subject

Heterotrimeric G protein

Somatostatin

Somatostatin receptor

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