Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.

F, Cappuzzo; FR, Hirsch; E, Rossi; S, Bartolini; GL, Ceresoli; L, Bemis; J, Haney; S, Witta; K, Danenberg; I, Domenichini; V, Ludovini; E, Magrini; V, Gregorc; C, Doglioni; A, Sidoni; M, Tonato; WA, Franklin; L, Crino; PA Jr, Bunn; M, Varella-Garcia

doi:10.1093/jnci/dji112

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Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.

Shared by NobleBlocks on May 1, 2005 • 12:00 AM UTC

Authors:

Cappuzzo F

Hirsch FR

Rossi E

Abstract

Background Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in many cancers, including non-small-cell lung cancer (NSCLC). We carried out a clinical study to compare the relationship between EGFR gene copy number, EGFR protein expressio...

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