Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

Cappuzzo, Federico; R. Hirsch, Fred; Rossi, Elisa; Bartolini, Stefania; Luca Ceresoli, Giovanni; Bemis, Lynne; Haney, Jerry; E. Witta, Samir; D. Danenberg, Kathleen; Domenichini, I.; Ludovini, Vienna; Magrini, Elisabetta; Gregorc, Vanesa; Doglioni, Claudio; Sidoni, Angelo; Tonato, Maurizio; A. Franklin, Wilbur; Crinò, Lucio; A. Bunn, Paul; Varella‐Garcia, Marileila

doi:10.1093/jnci/dji112

Public

Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

Published in JNCI Journal of the National Cancer Institute • May 3, 2005

Authors:

Federico Cappuzzo

Fred R. Hirsch

Elisa Rossi

Abstract

BACKGROUND: Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in many cancers, including non-small-cell lung cancer (NSCLC). We carried out a clinical study to compare the relationship between EGFR gene copy number, EGFR protein expressi...

Subject

Gefitinib

Epidermal growth factor receptor

Lung cancer

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!