Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Balasubramanyam, Karanam; A. Varier, Radhika; Altaf, Mohammad; Venkatesh, Swaminathan; B. Siddappa, Nagadenahalli; Ranga, Udaykumar; K. Kundu, Tapas

doi:10.1074/jbc.m409024200

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Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Published in Journal of Biological Chemistry • Sep 22, 2004

Authors:

Karanam Balasubramanyam

Radhika A. Varier

Mohammad Altaf

Abstract

Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral DNA that integrates into the human genome (e.g. the human immunodeficiency virus). Dysfunction of histone acetyltransferases (HAT...

Subject

Histone acetyltransferase

Histone Acetyltransferases

Acetylation

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