Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

L. Dawson, Valina; M. Dawson, Ted; D. London, Edythe; S. Bredt, David; H Snyder, S

doi:10.1073/pnas.88.14.6368

Public

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

Published in Proceedings of the National Academy of Sciences • Jul 15, 1991

Authors:

Valina L. Dawson

Ted M. Dawson

Edythe D. London

Abstract

Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels, cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate receptors in cerebellar slices. Nitric oxide synthase (EC 1.14.23.-) immunoreactivity is colocalized with nicotinamide...

Subject

Neurotoxicity

Sodium nitroprusside

Nitric oxide

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