IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

S. Hotamisligil, Gökhan; Peraldi, Pascal; Budavari, Adriane; Ellis, Ramsey; F. White, Morris; M. Spiegelman, Bruce

doi:10.1126/science.271.5249.665

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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Shared by NobleBlocks on Feb 2, 1996 • 12:00 AM UTC

Authors:

Gökhan S. Hotamisligil

Pascal Peraldi

Adriane Budavari

Abstract

Tumor necrosis factor-α (TNF-α) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor (IR). Treatment of cultured murine adipocytes with TNF-α was shown to induce serine phosphorylation of insulin r...

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