IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

S. Hotamışlıgil, Gökhan; Peraldi, Pascal; I. Budavari, Adriane; Ellis, Ramsey; F. White, Morris; M. Spiegelman, Bruce

doi:10.1126/science.271.5249.665

Public

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Published in Science • Feb 2, 1996

Authors:

Gökhan S. Hotamışlıgil

Pascal Peraldi

Adriane I. Budavari

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor (IR). Treatment of cultured murine adipocytes with TNF-alpha was shown to induce serine phosphorylation ...

Subject

Insulin resistance

Insulin receptor

Internal medicine

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